I've just purchased Adobe CS6 Design&Web, and I'm totally lost after all this time spent in CS4. It's going to take me a lot of time to feel there at home again. For now, all my work time is filled with hysterical laugh and constant WTFs, with my mood fluctuating from euphoria to depression. And it's after checking only new Illustrator, I don't know what's going to happen when I try Photoshop too!
I should've traced all these new options when they came out, I wouldn't be so lost now. Well... give me some time and I'll be back with new art, hopefully even better thanks to new tools.